HCID 58992710, compound → HCID 58992669, compound

HRID 602199Notes

Reaction equation

HRID 602199 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([CH2:14][NH:15][C:16]([CH:18]3[O:23][CH2:22][CH2:21][NH:20][CH2:19]3)=[O:17])=[C:11]([CH3:13])[N:12]=2)=[CH:4][CH:3]=1.[CH3:24][O:25][C:26]([C:28]1[CH:29]=[C:30](OB(O)O)[CH:31]=[CH:32][CH:33]=1)=[O:27]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][C:10]([CH2:14][NH:15][C:16]([CH:18]3[O:23][CH2:22][CH2:21][N:20]([C:32]4[CH:33]=[C:28]([CH:29]=[CH:30][CH:31]=4)[C:26]([O:25][CH3:24])=[O:27])[CH2:19]3)=[O:17])=[C:11]([CH3:13])[N:12]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 58992710HCID 58992710, compoundHCID 671702873-Methoxycarbonylphenylboric acid

Product 1

HCID 58992669HCID 58992669, compoundYield 71%

Procedure

Using N-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]methyl]morpholine-2-carboxamide (29.5 mg, 0.0838 mmol) and 3-(methoxycarbonyl)phenylboric acid (30.2 mg, 0.168 mmol), the same procedure was followed as in Example 2 to give 28.9 mg (71%) of the desired compound as a colorless oil.

Sources & evidence

ORD record
ord-856e12215a7f4dbebc7601e2b09eab8a
Source dataset
uspto-grants-2011_03
Patent number
US07902367B2

Reaction notes

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