Benzoic acid, 2-iodo-, methyl ester → HCID 58992642, compound

HRID 602200Notes

Reaction equation

HRID 602200 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([CH2:14][NH:15][C:16]([CH:18]3[O:23][CH2:22][CH2:21][NH:20][CH2:19]3)=[O:17])=[C:11]([CH3:13])[N:12]=2)=[CH:4][CH:3]=1.I[C:25]1[CH:34]=[CH:33][CH:32]=[CH:31][C:26]=1[C:27]([O:29][CH3:30])=[O:28]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][C:10]([CH2:14][NH:15][C:16]([CH:18]3[O:23][CH2:22][CH2:21][N:20]([C:25]4[CH:34]=[CH:33][CH:32]=[CH:31][C:26]=4[C:27]([O:29][CH3:30])=[O:28])[CH2:19]3)=[O:17])=[C:11]([CH3:13])[N:12]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 69132Benzoic acid, 2-iodo-, methyl esterHCID 58992710HCID 58992710, compound

Product 1

HCID 58992642HCID 58992642, compoundYield 86%

Procedure

Using N-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]methyl]morpholine-2-carboxamide (54.4 mg, 0.155 mmol) and methyl 2-iodobenzoate (40.6 mg, 0.155 mmol), the same procedure was followed as in Example 58 to give 64.5 mg (86%) of the desired compound as a colorless powder.

Sources & evidence

ORD record
ord-22f4bad7974a4ed5b87c3283723dcbad
Source dataset
uspto-grants-2011_03
Patent number
US07902367B2

Reaction notes

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