HCID 23077422, compound → HCID 58992632, compound

HRID 602203Notes

Reaction equation

HRID 602203 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([NH:7][C:8]([C:10]2[S:14][C:13]([C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=3)=[N:12][C:11]=2[CH3:22])=[O:9])[CH2:2]1.[CH:23]([C:25]1[CH:26]=[C:27](OB(O)O)[CH:28]=[CH:29][C:30]=1[F:31])=[O:24]>>[Cl:21][C:18]1[CH:17]=[CH:16][C:15]([C:13]2[S:14][C:10]([C:8]([NH:7][CH:3]3[CH2:4][CH2:5][CH2:6][N:1]([C:27]4[CH:28]=[CH:29][C:30]([F:31])=[C:25]([CH:26]=4)[CH:23]=[O:24])[CH2:2]3)=[O:9])=[C:11]([CH3:22])[N:12]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 23077422HCID 23077422, compoundHCID 57572201HCID 57572201, compound

Product 1

HCID 58992632HCID 58992632, compoundYield 17%

Procedure

Using N-(piperidin-3-yl)-2-(4-chlorophenyl)-4-methylthiazole-5-carboxamide (238 mg, 0.709 mmol) and 3-formyl-4-fluorophenylboric acid (238 mg, 1.42 mmol), the same procedure was followed as in Example 2 to give 55.0 mg (17%) of the desired compound as a pale yellow powder.

Sources & evidence

ORD record
ord-a1ef38d35f7a40448024008446605a95
Source dataset
uspto-grants-2011_03
Patent number
US07902367B2

Reaction notes

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