(R)-1-Boc-3-hydroxypiperidine → (R)-1-(tert-Butoxycarbonyl)-3-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]methoxy]piperidine

Participants

Role	Name	HCID	Charge
Reactant	(R)-1-Boc-3-hydroxypiperidine	HCID 1514398	—
Reactant	5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole	HCID 2763694	—
Product	(R)-1-(tert-Butoxycarbonyl)-3-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]methoxy]piperidine	HCID 58992677	78.5%

Reaction Steps

In an argon atmosphere, (R)-1-(tert-butoxycarbonyl)-3-hydroxypiperidine (604 mg, 3.00 mmol) and 5-chloromethyl-2-(4-chlorophenyl)-4-methylthiazole (775 mg, 3.00 mmol) were reacted in the same manner as in Step 6a of Example 6 to give 996 mg (78%) of the desired compound as a yellow oil.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07902367B2
Source dataset	uspto-grants-2011_03
ORD ID	ord-5243581fe5414ec389a0b6226dd06ac1
Source note	uspto-grants-2011_03