o-Fluorobenzaldehyde → HCID 58992696, compound

HRID 602211Notes

Reaction equation

[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[O:10][CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][NH:14][CH2:13]1.F[C:19]1[CH:26]=[CH:25][CH:24]=[CH:23][C:20]=1[CH:21]=[O:22]>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[O:10][CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][N:14]([C:19]2[CH:26]=[CH:25][CH:24]=[CH:23][C:20]=2[CH:21]=[O:22])[CH2:13]1

Participants

Reactant 2

HCID 67970o-Fluorobenzaldehyde

HCID 45786769HCID 45786769, compound

Product 1

HCID 58992696HCID 58992696, compoundYield 12.2%

Procedure

Using 3-[(benzothiazol-2-yl)oxymethyl]piperidine (58.0 mg, 0.234 mmol) and 2-fluorobenzaldehyde (0.0381 mL, 0.351 mmol), the same procedure was followed as in Step 1c of Example 1 to give 10.1 mg (12%) of the desired compound as a colorless oil.

Sources & evidence

ORD record: ord-174a82cb931945af91e099118b92f6f1
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07902367B2

Reaction notes

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