5-(4'-(Bromomethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetraazole → HCID 14987391, compound

HRID 602242Notes

Reaction equation

[CH2:1]([C:4]1[NH:8][C:7]([CH:9]=[O:10])=[CH:6][CH:5]=1)[CH2:2][CH3:3].Br[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[C:25]2[N:29]([C:30]([C:43]3[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=3)([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[N:28]=[N:27][N:26]=2)=[CH:15][CH:14]=1>>[CH2:1]([C:4]1[N:8]([CH2:12][C:13]2[CH:14]=[CH:15][C:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[C:25]3[N:29]([C:30]([C:43]4[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=4)([C:37]4[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=4)[C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)[N:28]=[N:27][N:26]=3)=[CH:17][CH:18]=2)[C:7]([CH:9]=[O:10])=[CH:6][CH:5]=1)[CH2:2][CH3:3]

Participants

Reactant 2

HCID 100534615-(4'-(Bromomethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetraazole

HCID 14987392HCID 14987392, compound

Product 1

HCID 14987391HCID 14987391, compoundYield 78%

Procedure

This compound was prepared using the same procedure as in Example 1. 3.9 g of 5-n-propyl-2-pyrrolaldehyde (0.031 moles) and 15 g of 4′-bromomethyl-2-(1-triphenylmethyltetrazol-5-yl)-biphenyl (0.031 moles) yield 15 g of product which are used in the subsequent step. Formula: C41H35N5O (m.w. 613.76). Yield 78%.

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-135fa263eb6a4f1bbe86ec66a1d5c39b
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07906501B2

Reaction notes

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