5-(4'-(Bromomethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetraazole → HCID 86615719, compound

HRID 602247Notes

Reaction equation

HRID 602247 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:10]=[O:11])[NH:5][C:6]=1[CH2:7][CH2:8][CH3:9].Br[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26]2[N:30]([C:31]([C:44]3[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=3)([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[N:29]=[N:28][N:27]=2)=[CH:16][CH:15]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:10]=[O:11])[N:5]([CH2:13][C:14]2[CH:15]=[CH:16][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[N:30]([C:31]([C:44]4[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=4)([C:38]4[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=4)[C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[N:29]=[N:28][N:27]=3)=[CH:18][CH:19]=2)[C:6]=1[CH2:7][CH2:8][CH3:9]

Participants

3

Reactant 2

HCID 100534615-(4'-(Bromomethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetraazoleHCID 86080200HCID 86080200, compound

Product 1

HCID 86615719HCID 86615719, compoundYield 60%

Procedure

This compound was prepared using the same procedure as in Example 1. 5.2 g of 4-chloro-5-n-propyl-2-pyrrolaldehyde (0.030 moles) and 16.9 g of 4′-bromomethyl-2-(1-triphenylmethyltetrazol-5-yl)biphenyl (0.030 moles) yield 12 g of product which are used in the subsequent step. Formula: C41H34ClN5O (m.w. 648.21). Yield 60%.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-248fe0d2f4494e4196927193b28e9a43
Source dataset
uspto-grants-2011_03
Patent number
US07906501B2

Reaction notes

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