HCID 178419901, compound → HCID 178507385, compound

HRID 602256Notes

Reaction equation

HRID 602256 reaction equation
[NH:1]1[C:13]2[C:12]3[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=3[N:6]=[CH:5][C:4]=2[N:3]=[CH:2]1.[NH:14]1[C:26]2[C:25]3[N:24]=[CH:23][CH:22]=[CH:21][C:20]=3[N:19]=[CH:18][C:17]=2[N:16]=[CH:15]1>>[NH:1]1[C:13]2[C:12]3[C:7](=[C:8]([NH2:14])[CH:9]=[CH:10][CH:11]=3)[N:6]=[CH:5][C:4]=2[N:3]=[CH:2]1.[NH:14]1[C:26]2[C:25]3[C:20](=[C:21]([NH2:1])[CH:22]=[CH:23][N:24]=3)[N:19]=[CH:18][C:17]=2[N:16]=[CH:15]1

Participants

4

Reactant 2

HCID 178419901HCID 178419901, compoundHCID 1784207351h-Imidazo[4,5-c][1,5]naphthyridine

Product 2

HCID 178507385HCID 178507385, compoundHCID 178507867HCID 178507867, compound

Procedure

In steps (6) and (7) of Reaction Scheme VI, a 1H-imidazo[4,5-c]quinoline or 1H-imidazo[4,5-c][1,5]naphthyridine of Formula LVI is oxidized and then aminated to provide a 1H-imidazo[4,5-c]quinolin-6-amine or 1H-imidazo[4,5-c][1,5]naphthyridin-6-amine of Formula LVIII, a subgenus of Formulas I, II, III, and IV. Steps (6) and (7) of Reaction Scheme VI can be carried out as described in steps (5) and (6) of Reaction Scheme I.

Sources & evidence

ORD record
ord-537658a12c534695916eeff3553b57f6
Source dataset
uspto-grants-2011_03
Patent number
US07906506B2

Reaction notes

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