Sodium Carbonate → HCID 67273561, compound

Participants

Reaction Steps

A solution of (11S)-8,11-dimethyl-10,11-dihydro-8H-[1,4]oxazino[4′,3′:1,2]imidazo[4,5-c]quinoline (80 mg, 0.316 mmol) and 5 mL of CHCl3 was treated with MCPBA (meta-chloroperoxybenzoic acid) (93 mg, 77% max). After 18 hours, the reaction was treated with ˜10 mL of CHCl3 and 5 mL of 2% Na2CO3 solution and the layers were separated. The aqueous layer was extracted with CHCl3 (5×10 mL). The organic layers were combined then washed with brine, dried over Na2SO4, filtered, and concentrated to give (11S)-8,11-dimethyl-10,11-dihydro-8H-[1,4]oxazino[4′,3′:1,2]imidazo[4,5-c]quinoline 5-oxide (85 mg) as a light yellow solid.

Provenance & Evidence