Piperidine → HCID 59684256, compound

Participants

Reaction Conditions

Reaction Steps

To 2-[7-(3-chloromethylphenyl)-3-(3-chlorophenyl)-1-oxo-1H-isoquinolin-2-yl]-N-isopropylacetamide (19 mg, 0.04 mmol) in DCM (5 mL) was added piperidine (0.5 mL) and this was stirred at 23° C. for 18 h. The mixture was concentrated in vacuo, and the crude residue purified by preparative HPLC to yield the HCl salt of 2-[3-(3-chlorophenyl)-1-oxo-7-(3-piperidin-1-ylmethylphenyl)-1H-isoquinolin-2-yl]-N-isopropylacetamide (EXAMPLE 35) hydrochloride salt (7 mg, 0.013 mmol, 33%) as pale beige solid.

Provenance & Evidence