HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid → 4-Amino-n-[{4-[(1-(tert-butoxycarbonyl)-4-piperidinyl)methyl]-2-morpholinyl}-methyl]-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid | HCID 10632401 | — |
| Reactant | 4-amino-N-[{4-[(1-(tert-butoxycarbonyl)-4-piperidinyl)methyl]-2-morpholinyl}-methyl]-5-chloro-2-methoxybenzamide | HCID 59510471 | — |
| Product | 4-Amino-n-[{4-[(1-(tert-butoxycarbonyl)-4-piperidinyl)methyl]-2-morpholinyl}-methyl]-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxamide | HCID 59510481 | — |
Reaction Steps
In place of 4-amino-5-chloro-2-methoxybenzoic acid of Example 1, 4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid was treated in the similar manner to Example 1 to give the titled compound as an amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07906510B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-542faacc18b74aa0b37940b1d4efced0 |
| Source note | uspto-grants-2011_03 |