Azetidine → HCID 67055781, compound

Participants

Reaction Steps

A solution of (S)-4-amino-5-chloro-2-ethoxy-N-[{4-[(1-imidazolecarbonyl-4-piperidinyl)-methyl]-2-morpholinyl}methyl]benzamide (Example 206) (1.07 g) and azetidine (0.25 g) in THF (15 ml) was heated to reflux for 19 hours with stirring. After cooling to room temperature, the reaction solution was dried under reduced pressure to be solidified, and the residue was purified by silica gel column chromatography (eluent: chloroform/methanol=10/1) to give the titled compound (0.43 g) as a white solid. Melting point 166-168° C. (recrystallized from EA/H)

Provenance & Evidence