HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-anilino4-methoxy-N-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Methylamine hydrochloride | HCID 6364545 | — |
| Reactant | 2-Anilino-4-methoxybenzoic acid | HCID 12648027 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-anilino4-methoxy-N-methylbenzamide | HCID 66646224 | — |
Reaction Steps
2-anilino-4-methoxybenzoic acid (220 mg), methylamine hydrochloride (100 mg), triethylamine (0.31 mL), EDC (260 mg), and HOBt (210 mg) were combined in 4 mL DMF and stirred overnight at room temp. The reaction was diluted with EtOAc and washed with 10% citric acid (1×), water, and 10% sodium bicarbonate, then dried (Na2SO4) concentrated to give 0.23 g of 2-anilino-4-methoxy-N-methylbenzamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07906521B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-1089c6cb240045799ecc10e4f5bd8737 |
| Source note | uspto-grants-2011_03 |