Cesium carbonate → HCID 11370694, compound

Participants

Reaction Steps

Following the procedure for 6-methoxy-4-phenyl-2,3,3a,4-tetrahydropyrrolo[2,1-b]quinazolin-9(1H)-one, using 6-bromohexanoyl chloride in place of 4-bromobutyryl chloride, 410 mg of an intermediate presumed to be 2-(4-bromobutyl)-7-methoxy-1-phenyl-2,3-dihydroquinazolin-4(1H)-one. 200 mg of this material was dissolved in 2 mL DMF and treated with cesium carbonate (450 mg). The reaction was stirred at room temp for 72 h, then partitioned between EtOAc and water. The organic solution was dried (Na2SO4) and concentrated. Flash chromatography (50% EtOAc in hexanes) gave the titled compound.

Provenance & Evidence