Pivaloyl chloride → HCID 58828609, compound

Participants

Reaction Steps

To a solution of 2-anilino-4-methoxybenzamide (150 mg) in 5 mL dichloroethane was added pivaloyl chloride (0.229 mL), and the reaction was heated at reflux for 7 h. The reaction was cooled and partially concentrated, then diluted with ethyl ether, and the resulting precipitate was isolated by filtration to give 180 mg of a solid product. This material was dissolved in CH2Cl2 and washed with 10% sodium carbonate. The organic solution was dried (Na2SO4) and concentrated to give the titled compound.

Provenance & Evidence