Potassium hydroxy sulfite → HCID 58691262, compound

HRID 602326Notes

Reaction equation

HRID 602326 reaction equation
O[O:2][S:3]([O-:5])=O.[K+].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15]([N:17]2[C@@H:21]([C:22]([NH:24][C:25]3[CH:30]=[CH:29][C:28]([N:31]4[CH2:36][CH2:35][O:34][CH2:33][C:32]4=[O:37])=[CH:27][CH:26]=3)=[O:23])[CH2:20]S[CH2:18]2)=[O:16])=[CH:10][CH:9]=1>O.CO>[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15]([N:17]2[C@@H:21]([C:22]([NH:24][C:25]3[CH:30]=[CH:29][C:28]([N:31]4[CH2:36][CH2:35][O:34][CH2:33][C:32]4=[O:37])=[CH:27][CH:26]=3)=[O:23])[CH2:20][S:3](=[O:5])(=[O:2])[CH2:18]2)=[O:16])=[CH:10][CH:9]=1

Participants

5

Reactant 2

HCID 23707502Potassium hydroxy sulfiteHCID 58691296HCID 58691296, compound

Product 1

HCID 58691262HCID 58691262, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent2×

Procedure

3.3 A solution of 1.9 g of oxone in 30 ml of water is added to a suspension of 450 mg (0.976 mmol) of “A3” in 50 ml of methanol, and the reaction mixture is stirred at room temperature for 24 hours. The reaction mixture is added to water, and the precipitate formed is filtered off and dried, giving 3-N-[(4-chlorophenyl)]-4-N-{[4-(3-oxomorpholin-4-yl)phenyl]}-(S)-1,1-dioxo-1λ6-thiazolidine-3,4-dicarboxamide (“A4”) as a colourless solid; ESI 493.

Workup

  1. customthe precipitate formed
  2. filtrationis filtered off
  3. customdried

Sources & evidence

ORD record
ord-575dfa0a60854da6bff6369f61603196
Source dataset
uspto-grants-2011_03
Patent number
US07906516B2

Reaction notes

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