HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Chloroethoxy)acetyl chloride → Ethyl {4-[2-(2-chloroethoxy)acetylamino]phenyl}acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Chloroethoxy)acetyl chloride | HCID 19048420 | — |
| Reactant | Ethyl (4-aminophenyl)acetate--hydrogen chloride (1/1) | HCID 24192282 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl {4-[2-(2-chloroethoxy)acetylamino]phenyl}acetate | HCID 58691225 | — |
Reaction Steps
14.6 g (92.7 mmol) of (2-chloroethoxy)acetyl chloride are added to a suspension of 20.0 g (92.7 mmol) of ethyl 4-aminophenylacetate hydrochloride in 25 ml of toluene, and the mixture is heated at the boil for 24 hours. The reaction mixture is evaporated and dried, giving ethyl {4-[2-(2-chloroethoxy)acetylamino]phenyl}acetate as a yellowish solid; ESI 300.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07906516B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-5e128d9d77c543eb915b125896f28f68 |
| Source note | uspto-grants-2011_03 |