反应详情

温度

80 °C

2-Chloro-4-nitropyridine (2.0 g, 12.2 mmol) was dissolved in THF (30 mL) and the solution was added with pyrrolidine (3.25 mL, 38.9 mmol), followed by stirring at 80° C. overnight. After an insoluble matter of the reaction mixture was filtered off, the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane=20/80) to obtain 4-nitro-2-(pyrrolidin-1-yl)pyridine (560 mg, 24%).

1. filtrationAfter an insoluble matter of the reaction mixture was filtered off
2. customthe solvent was evaporated under reduced pressure
3. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane=20/80)