Thionyl Chloride → 2-Chloropyridine-4-carbonyl chloride

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloro-isonicotinic acid (15 g, 95.2 mmol) and thionyl chloride (90 mL) was heated at 100° C. After completion of the reaction the mixture was concentrated in vacuo. Residual thionyl chloride was removed by azeotropic distillation with toluene, to give 2-chloro-isonicotinoyl chloride (15.33 g).

Provenance & Evidence