Ethyl 2-(5-nitropyridin-2-YL)acetate → Ethyl 2-(5-aminopyridin-2-yl)acetate

Participants

Reaction Steps

The mixture of ethyl (5-nitropyridin-2-yl)acetate (3.27 g, 15.6 mmol, step 2 of Example 1) and 5 wt. % palladium on carbon (320 mg) in methanol (25 mL) was stirred under hydrogen (1 atom) at room temperature for 4 h. The mixture was filtered through a pad of Celite washing with methanol and the filtrate was concentrated to give 2.98 g (quant.) of the title compound as a yellow oil.

Provenance & Evidence