反应详情

The mixture of N-[cis-1-benzyl-6-(2-hydroxyethyl)piperidin-3-yl]-1-isopropyl-1H-indazole-3-carboxamide (276 mg, 0.66 mmol, step 9 of Example 1) and 10 wt. % palladium on carbon (30 mg) in methanol (5 mL) was stirred under hydrogen (1 atom) at room temperature for 4 h. The mixture was filtered through a pad of Celite washing with methanol and the filtrate was concentrated under reduced pressure. The resulting residue was chromatographed on a column of silica gel eluting with dichloromethane/methanol/25% ammonium hydroxide (10:1:0.2) to give 146 mg (67%) of the title compound as a white crystal.

1. filtrationThe mixture was filtered through a pad of Celite
2. washwashing with methanol
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe resulting residue was chromatographed on a column of silica gel eluting with dichloromethane/methanol/25% ammonium hydroxide (10:1:0.2)