Lithium borohydride → HCID 67271041, compound

Participants

Reaction Steps

To a stirred solution of tert-butyl cis-2-(3-ethoxy-3-oxopropyl)-5-{[(1-isopropyl-1H-indazol-3-yl) carbonyl]amino}piperidine-1-carboxylate (300 mg, 0.617 mmol, step 7 of Example 5) in tetrahydrofuran (7 mL) was added at 0° C. a solution of lithium borohydride (2M in tetrahydrofuran, 1.54 mL, 3.08 mmol), and the mixture was stirred at room temperature for 20 h. The mixture was quenched with water (20 mL), extracted with ethyl acetate (30 mL×3). The combined organic layer was washed with brine (20 mL), dried over magnesium sulfate and concentrated under reduced pressure to give 282 mg (quant.) of the title compound as a colorless oil. The resulting residue was used for the next reaction without purification.

Provenance & Evidence