HCID 10692325, compound → HCID 10621099, compound

Participants

Reaction Steps

To a stirred solution of tert-butyl (2S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-[(1E)-3-ethoxy-3-oxoprop-1-en-1-yl]pyrrolidine-1-carboxylate (1.37 g, 3.4 mmol, J. Antibiotics, 1997, 50, 567-585) in ethanol (30 mL) was added 10 wt. % palladium on carbon (140 mg). The resulting mixture was stirred under hydrogen (4 atom) at room temperature for 3 h. The mixture was filtered through a pad of Celite and the filter cake was washed with ethanol. The combined filtrate was concentrated to give 1.34 g (97%) of the title compound as a colorless oil.

Provenance & Evidence