5-Fluoro-1-isopropyl-1H-indazole-3-carboxylic acid → tert-Butyl (2S,4S)-4-{[(5-fluoro-1-isopropyl-1H-indazol-3-yl)carbonyl]amino}-2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate

HRID 602481Notes

Reaction equation

HRID 602481 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH:11]([CH3:13])[CH3:12])[N:6]=[C:5]2[C:14]([OH:16])=O.[NH2:17][C@@H:18]1[CH2:22][N:21]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[C@H:20]([CH2:30][C:31]([O:33][CH3:34])=[O:32])[CH2:19]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH:11]([CH3:12])[CH3:13])[N:6]=[C:5]2[C:14]([NH:17][C@@H:18]1[CH2:22][N:21]([C:23]([O:25][C:26]([CH3:27])([CH3:28])[CH3:29])=[O:24])[C@H:20]([CH2:30][C:31]([O:33][CH3:34])=[O:32])[CH2:19]1)=[O:16]

Participants

3

Reactant 2

HCID 672701085-Fluoro-1-isopropyl-1H-indazole-3-carboxylic acidHCID 67271206HCID 67271206, compound

Product 1

HCID 67271330tert-Butyl (2S,4S)-4-{[(5-fluoro-1-isopropyl-1H-indazol-3-yl)carbonyl]amino}-2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 7 from 5-fluoro-1-isopropyl-1H-indazole-3-carboxylic acid (step 2 of Example 11) and tert-butyl (2S,4S)-4-amino-2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate (step 4 of Example 9).

Sources & evidence

ORD record
ord-89370b56b7df4e129e272602a76edc68
Source dataset
uspto-grants-2011_03
Patent number
US07906532B2

Reaction notes

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