Methanesulfonyl chloride → HCID 67270743, compound

HRID 602489Notes

Reaction equation

[NH2:1][CH2:2][C@@H:3]1[CH2:7][C@H:6]([NH:8][C:9]([C:11]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]([CH:20]([CH3:22])[CH3:21])[N:12]=2)=[O:10])[CH2:5][N:4]1[C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24].[CH3:30][S:31](Cl)(=[O:33])=[O:32]>>[CH:20]([N:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]([C:9]([NH:8][C@@H:6]2[CH2:5][N:4]([C:23]([O:25][C:26]([CH3:27])([CH3:29])[CH3:28])=[O:24])[C@H:3]([CH2:2][NH:1][S:31]([CH3:30])(=[O:33])=[O:32])[CH2:7]2)=[O:10])=[N:12]1)([CH3:21])[CH3:22]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 67270764HCID 67270764, compound

Product 1

HCID 67270743HCID 67270743, compound

Procedure

The title compound was prepared according to the procedure described in step 3 of Example 17 from tert-butyl (2S,4S)-2-(aminomethyl)-4-{[(1-isopropyl-1H-indazol-3-yl)carbonyl]amino}pyrrolidine-1-carboxylate (step 2 of Example 17) and methanesulfonyl chloride.

Sources & evidence

ORD record: ord-6190134fe9bb42178a254d0e34f048be
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07906532B2

Reaction notes

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