Ammonium Hydroxide → HCID 67271025, compound

Participants

Reaction Steps

The mixture of tert-butyl (2S,4S)-2-(cyanomethyl)-4-{[(1-isopropyl-1H-indazol-3-yl)carbonyl]amino}pyrrolidine-1-carboxylate (0.40 g, 0.97 mmol, Step 1 of Example 19) and catalytic Raney-Ni in methanol (16 mL) and 25% ammonium hydroxide (4.0 mL) was stirred under hydrogen (4 atom) at room temperature for 7 h. The mixture was filtered through a pad of Celite. The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane/ethyl acetate 1:1 to dichloromethane/methanol 10:1) to give 115 mg (65%) of the title compound as a colorless oil.

Provenance & Evidence