5-fluoro-1H-indazole-3-carboxylic acid → HCID 67270785, compound

HRID 602493Notes

Reaction equation

HRID 602493 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[C:11]([OH:13])=O.[NH2:14][C@@H:15]1[CH2:19][N:18]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[C@H:17]([CH2:27][C:28]([O:30][CH3:31])=[O:29])[CH2:16]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[C:11]([NH:14][C@@H:15]1[CH2:19][N:18]([C:20]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:21])[C@H:17]([CH2:27][C:28]([O:30][CH3:31])=[O:29])[CH2:16]1)=[O:13]

Participants

3

Reactant 2

HCID 149990525-fluoro-1H-indazole-3-carboxylic acidHCID 67271206HCID 67271206, compound

Product 1

HCID 67270785HCID 67270785, compound

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 7 from 5-fluoro-1H-indazole-3-carboxylic acid (J. Heterocyclic Chem. 1964, 1, 239) and tert-butyl (2S,4S)-4-amino-2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate (step 4 of Example 9).

Sources & evidence

ORD record
ord-60e8476d009e4d55b65612d7652bbfa5
Source dataset
uspto-grants-2011_03
Patent number
US07906532B2

Reaction notes

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