Dimethylamine → HCID 67271335, compound

HRID 602495Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:12][C@@H:11]([NH:13][C:14]([C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([F:25])[CH:23]=3)[N:18]([CH:26]([CH3:28])[CH3:27])[N:17]=2)=[O:15])[CH2:10][C@H:9]1[CH2:29][C:30](O)=[O:31])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:33][NH:34][CH3:35]>>[CH3:33][N:34]([CH3:35])[C:30](=[O:31])[CH2:29][C@@H:9]1[CH2:10][C@H:11]([NH:13][C:14]([C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([F:25])[CH:23]=3)[N:18]([CH:26]([CH3:27])[CH3:28])[N:17]=2)=[O:15])[CH2:12][N:8]1[C:6]([O:5][C:1]([CH3:3])([CH3:4])[CH3:2])=[O:7]

Participants

Reactant 2

HCID 674Dimethylamine

HCID 67270344HCID 67270344, compound

Product 1

HCID 67271335HCID 67271335, compound

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 7 from ((2S,4S)-1-(tert-butoxycarbonyl)-4-{[(5-fluoro-1-isopropyl-1H-indazol-3-yl)carbonyl]amino}pyrrolidin-2-yl)acetic acid (step 3 of Example 25) and dimethylamine.

Sources & evidence

ORD record: ord-7128cfae0ba243a0be027b137e8dab4f
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07906532B2

Reaction notes

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