Methanesulfonyl chloride → HCID 67270767, compound

HRID 602497Notes

Reaction equation

[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([NH:15][C@@H:16]2[CH2:20][N:19]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[C@H:18]([CH2:28][NH:29][CH3:30])[CH2:17]2)=[O:14])=[N:5]1)([CH3:3])[CH3:2].[CH3:31][S:32](Cl)(=[O:34])=[O:33]>>[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([NH:15][C@@H:16]2[CH2:20][N:19]([C:21]([O:23][C:24]([CH3:25])([CH3:27])[CH3:26])=[O:22])[C@H:18]([CH2:28][N:29]([CH3:30])[S:32]([CH3:31])(=[O:34])=[O:33])[CH2:17]2)=[O:14])=[N:5]1)([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 67270392HCID 67270392, compound

Product 1

HCID 67270767HCID 67270767, compound

Procedure

The title compound was prepared according to the procedure described in step 3 of Example 17 from tert-butyl (2S,4S)-4-{[(1-isopropyl-1H-indazol-3-yl)carbonyl]amino}-2-[(methylamino)methyl]pyrrolidine-1-carboxylate (step 1 of Example 26) and methanesulfonyl chloride.

Sources & evidence

ORD record: ord-cb28156fc49e4eb089bb6e8ff3c28a3a
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07906532B2

Reaction notes

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