Triethylamine → HCID 86607171, compound

Participants

Reaction Steps

To a solution of N(4)-(5-Chloro-thiophen-2-ylmethyl)-2,N(4)-dimethyl-benzene-1,4-diamine (54 mg, 0.20 mmol) and triethylamine (84 μL, 0.60 mmol) in dry tetrahydrofuran (1 mL) was added pentanoyl chloride (36 μL, 0.30 mmol), and the mixture was stirred for 1 hour at room temperature after which it was partitioned between saturated aqueous sodium bicarbonate (5 mL) and ethyl acetate (5 mL). The organic layer was dried over sodium sulfate, volatiles were evaporated, and the residue was purified on a FlashMaster system (silica, eluted with heptane/ethyl acetate mixtures) to yield the title compound as a white solid (61 mg, 86%).

Provenance & Evidence