Potassium Carbonate → HCID 67267387, compound

Participants

Reaction Conditions

Reaction Steps

{4-[(5-Chloro-thiophen-2-ylmethyl)-amino]-2-iodophenyl}-carbamic acid ethyl ester (15 mg), 3-quinolineboronic acid (29.7 mg), palladium(II) acetate (ca. 1 mg), potassium carbonate (0.035 mL, 5M aqueous solution), and acetone (2 mL) were mixed and heated in heated in a sealed glass tube in a microwave synthesizer for 10 minutes at 125° C. After cooling to room temperature, the reaction mixture was extracted with ethyl acetate (4 mL), the organic phase washed with water (2×2 mL), and brine (2×2 mL), dried over magnesium sulfate, and filtered. The solvent was removed in vacuo, and the crude product was purified by preparative LC-MS. The collected fraction was evaporated in: vacuo, redissolved in ethyl acetate (5 mL), and the organic phase was washed with saturated aqueous sodium bicarbonate (3 mL), water (3 mL), and brine (2×2 mL). The organic phase was dried over magnesium sulfate, filtered, and the solvent was removed in vacuo to furnish the title compound (5 mg, 33%).

Provenance & Evidence