HCID 67152644, compound → HCID 67152403, compound

HRID 602558Notes

Reaction equation

HRID 602558 reaction equation
[CH2:1]([O:3][C:4](=[O:38])/[C:5](=[CH:9]/[C:10]1[C:18]2[C:13](=[CH:14][N:15]=[C:16]([C:19]3[C:24]([CH2:25][CH3:26])=[CH:23][CH:22]=[CH:21][C:20]=3[CH2:27][CH3:28])[CH:17]=2)[N:12]([C:29]2[CH:34]=[CH:33][C:32]([CH:35]([CH3:37])[CH3:36])=[CH:31][CH:30]=2)[CH:11]=1)/[CH2:6][CH2:7][CH3:8])[CH3:2]>[Pd].CCO>[CH2:1]([O:3][C:4](=[O:38])[CH:5]([CH2:9][C:10]1[C:18]2[C:13](=[CH:14][N:15]=[C:16]([C:19]3[C:24]([CH2:25][CH3:26])=[CH:23][CH:22]=[CH:21][C:20]=3[CH2:27][CH3:28])[CH:17]=2)[N:12]([C:29]2[CH:34]=[CH:33][C:32]([CH:35]([CH3:36])[CH3:37])=[CH:31][CH:30]=2)[CH:11]=1)[CH2:6][CH2:7][CH3:8])[CH3:2]

Participants

4

Reactant 1

HCID 67152644HCID 67152644, compound

Product 1

HCID 67152403HCID 67152403, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of (2-[1-[5-(2,6-diethyl-phenyl)-1-(4-isopropyl-phenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-meth-(E)-ylidene]-pentanoic acid ethyl ester (120 mg, 0.23 mmol), 10% Pd/C (20 mg), and EtOH (4 mL) is stirred under hydrogen (1 atm) for 18 h at room temperature. The mixture is filtered over celite and concentrated under reduced pressure to afford 2-[5-(2,6-diethyl-phenyl)-1-(4-isopropyl-phenyl)-1H-pyrrolo[2,3-c]pyridin-3-ylmethyl]-pentanoic acid ethyl ester as colorless oil.

Workup

  1. filtrationThe mixture is filtered over celite and
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-1e8d990f08924b7680bef2710604006c
Source dataset
uspto-grants-2011_03
Patent number
US07906528B2

Reaction notes

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