HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Azetidin-3-yl(3,5-difluorophenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1,1-Dimethylethyl 3-(3,5-difluorobenzoyl)-1-azetidinecarboxylate | HCID 67065905 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Azetidin-3-yl(3,5-difluorophenyl)methanone | HCID 67065914 | — |
Reaction Steps
A solution of 400 mg (1.35 mmol) of tert-butyl 3-(3,5-difluorobenzoyl)azetidine-1-carboxylate in 6 mL of HCl in dioxane (4M) and 2.5 mL of TFA was stirred for 4 h at 50° C. The reaction mixture was concentrated, and the residue was washed with hexanes/ether (1/1) to afford the title compound. Mass Spectrum: m/e=199 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07906503B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-690a8d1c6f9d4259be1f5ae100ea3c17 |
| Source note | uspto-grants-2011_03 |