4-Nitrophenyl chloroformate → HCID 57559940, compound

Participants

Reaction Steps

To a solution of 420 mg (0.91 mmol) of 1-{1-[bis(4-chlorophenyl)methyl]azetidin-3-ylidene}-1-(3,5-difluorophenyl)propan-2-ol (Example 35) and 222 mg (1.82 mmol) of 4-dimethylaminopyridine in 10 mL of methylene chloride was added 276 mg (1.37 mmol) of 4-nitrophenyl chloroformate, followed by stirring for 4 h at rt. The reaction mixture was concentrated, and the residue was purified by silica gel chromatography with hexanes/ethyl acetate=12:1 to afford the title compound. Mass Spectrum: m/e=627 (M+1 35Cl, 35Cl) and 629 (M+1 35Cl, 37Cl).

Provenance & Evidence