Isopropylamine → HCID 11330230, compound

Participants

Reaction Steps

To a solution of 45 mg (0.073 mmol) of 2-{1-[bis(4-chlorophenyl)methyl]azetidin-3-ylidene}-2-(3,5-difluorophenyl)-1-methylethyl 4-nitrophenyl carbonate (Example 37) in 3 mL of methylene chloride was added 0.3 mL of isopropylamine, followed by stirring for 4 h at rt. The reaction mixture was concentrated and the residue was purified by silica gel chromatography with hexanes/ethyl acetate=4:1 to afford the title compound; Mass Spectrum: m/e=545 (M+1 35Cl, 35Cl) and 547 (M+1 35Cl, 37Cl).

Provenance & Evidence