Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1) → HCID 67011784, compound

HRID 602782Notes

Reaction equation

HRID 602782 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:8]([C:11]([F:24])([C:18]2[O:19][C:20]([CH3:23])=[N:21][N:22]=2)[CH:12]2[CH2:16][CH2:15][C:14](=O)[CH2:13]2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.Cl.[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([NH:33]N)=[CH:29][CH:28]=1.ClC1C2C3(CCC=2)C(=CC=1)NC(C(S(C1C=CC=C(Cl)C=1)(=O)=O)(F)C1OC(C)=NN=1)C3>>[Cl:26][C:27]1[CH:32]=[CH:31][C:30]2[NH:33][C:14]3[CH2:13][CH:12]([C:11]([S:8]([C:4]4[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=4)(=[O:10])=[O:9])([F:24])[C:18]4[O:19][C:20]([CH3:23])=[N:21][N:22]=4)[CH2:16][C:15]=3[C:29]=2[CH:28]=1

Participants

4

Reactant 3

HCID 71600Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1)HCID 67266836HCID 67266836, compoundHCID 67266915HCID 67266915, compound

Product 1

HCID 67011784HCID 67011784, compound

Procedure

In analogy to example 74.6, from (RS,SR)-3-[(3-chloro-benzenesulfonyl)-fluoro-(5-methyl-[1,3,4]oxadiazol-2-yl)-methyl]-cyclopentanone and (4-chloro-phenyl)-hydrazine hydrochloride was prepared (RS,SR)-7-chloro-2-[(3-chloro-benzenesulfonyl)-fluoro-(5-methyl-[1,3,4]oxadiazol-2-yl)-methyl]-1,2,3,4-tetrahydro-cyclopenta[D]indole as a light brown solid, MS: 480 (MH+).

Sources & evidence

ORD record
ord-70789a157326412ca2a9d1353fac5b5d
Source dataset
uspto-grants-2011_03
Patent number
US07906546B2

Reaction notes

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