HCID 46898224, compound → HCID 46898225, compound

Participants

Reaction Steps

A solution of 22 mg (0.05 mmol) (RS, SR)-7-chloro-2-[(3-ethynyl-benzenesulfonyl)-fluoro-(5-methyl-[1,3,4]oxadiazol-2-yl)-methyl]-1,2,3,4-tetrahydro-cyclopenta[b]indole in 0.5 mL of methanol was treated with 1 mg of palladium on activated charcoal (10%) and stirred intensely under H2 (atmospheric pressure) during 5 hrs. Filtration and evaporation of the solvent gave 21 mg (92%) of (RS, SR) 7-chloro-2-[(3-ethyl-benzenesulfonyl)-fluoro-(5-methyl-[1,3,4]oxadiazol-2-yl)-methyl]-1,2,3,4-tetrahydro-cyclopenta[b]indole, as a yellow solid, MS: 475 (MH+)

Provenance & Evidence