Water → HCID 46898436, compound

Participants

Reaction Steps

A solution of 12 mg (0.02 mmol) of (RS, SR) 4-[5-[(3-bromo-benzenesulfonyl)-(7-chloro-1,2,3,4-tetrahydro-cyclopenta[b]indol-2-yl)-fluoro-methyl]-[1,3,4]oxadiazol-2-yl}-benzoic acid methyl ester in 0.5 mL of THF was treated with 3 mg (0.08 mmol) of lithium aluminiumhydride and stirred at RT for one hour. The mixture was treated with a mixture of ice cubes and water and extracted twice with dichlormothane. Drying of the combined organic phases over Na2SO4, filtration and evaporation gave 10 mg (86%) of (RS, SR) (4-{5-[(3-bromo-benzenesulfonyl)-(7-chloro-1,2,3,4-tetrahydro-cyclopenta[b]indol-2-yl)-fluoro-methyl]-[1,3,4]oxadiazol-2-yl}-phenyl)-methanol as a yellow solid, MS: 618 (MH+, 1Br).

Provenance & Evidence