HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 602821Generated: October 28, 2026
Ethyl Acetate → Ethyl 2-methyl-1,3-oxazole-4-carboxylate
https://huagongshe.com/reaction/602821
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Potassium 2-ethoxycarbonyl-2-(1-ethoxy-ethylideneamino)-ethenolate | HCID 86600794 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Ethyl 2-methyl-1,3-oxazole-4-carboxylate | HCID 10402496 | 45% |
Reaction Steps
5 g (25 mmol) of potassium 2-ethoxycarbonyl-2-(1-ethoxy-ethylideneamino)-ethenolate were completely dissolved in 15 mL acetic acid at RT, and then the solution was heated to 110° C. overnight. After cooling down, 100 mL EtOAc were added and the solution is neutralized with saturated NaHCO3 solution. The organic phase was separated, dried over Na2SO4, filtered and evaporated. Column chromatography on silica gel (heptane/EtOAc 1:2) yielded 1.74 g (45%) of 2-methyl-oxazole-4-carboxylic acid ethyl ester as an yellow oil, MS: 156 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07906546B2 |
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| Source dataset | uspto-grants-2011_03 |
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| ORD ID | ord-c04230959fd24adb8c67e3a051985410 |
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| Source note | uspto-grants-2011_03 |
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