Methyl azetidine-3-carboxylate hydrochloride → HCID 57948587, compound

HRID 602827Notes

Reaction equation

HRID 602827 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C@H:9]([CH3:25])[CH2:10][O:11][C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[C:18]([CH3:22])=[C:17](C=O)[CH2:16][CH2:15]3)=[CH:4][CH:3]=1.CNCCC([O-])=O.Cl.[NH:34]1[CH2:37][CH:36]([C:38]([O:40][CH3:41])=[O:39])[CH2:35]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C@H:9]([CH3:25])[CH2:10][O:11][C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[C:18]([CH3:22])=[C:17]([CH2:35][NH:34][CH2:37][CH2:36][C:38]([O:40][CH3:41])=[O:39])[CH2:16][CH2:15]3)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 21100040Methyl azetidine-3-carboxylate hydrochlorideHCID 21893947HCID 21893947, compoundHCID 86635608HCID 86635608, compound

Product 1

HCID 57948587HCID 57948587, compound

Procedure

The procedure of Example 6 was similarly performed while using 6-{[(2S)-3-(4-chlorophenyl)-2-methylpropyl]oxy}-1-methyl-3,4-dihydronaphthalene-2-carbaldehyde as a substitute for the compound prepared in Example 5 and using methyl-β-alaninate as a substitute for methyl azetidine-3-carboxylate hydrochloride. Thus, the title compound having the following physical properties was obtained.

Sources & evidence

ORD record
ord-86e3e8d955ae4fe8a02cb327f65d9e5b
Source dataset
uspto-grants-2011_03
Patent number
US07906549B2

Reaction notes

Loading…