HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-6-fluorophenol → Methyl 7-fluorobenzo[d]oxazole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-6-fluorophenol | HCID 643562 | — |
| Reactant | Methyl 2,2,2-trimethoxyacetate | HCID 12586559 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 7-fluorobenzo[d]oxazole-2-carboxylate | HCID 59536124 | 53.3% |
Reaction Steps
A solution of 2-amino-6-fluorophenol (14) (254 mg, 2 mmol) and methyl 2,2,2-trimethoxyacetate (15) (328 mg, 2 mmol) in 3 ml MeOH was heated in micro wave reactor at 140° C. for 1 h. After cooling down to r.t. crystals formed. Filtration followed by washing with MeOH furnished 208 mg of methyl 7-fluorobenzoxazole-2-carboxylate (16) as brown needles. Yield: 53.3%. LC-MS: calculated M=195.15; observed M=195.96.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07906553B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-bb2edee9777e4c80854a58022966e88a |
| Source note | uspto-grants-2011_03 |