Triethylamine → HCID 86612741, compound

Participants

Reaction Steps

The mixture of 240 mg (0.45 mmol) of 3-[(S)-{3-[(1S)-1-(3-bromo-5-fluorophenyl)-2-fluoro-2-methylpropyl]azetidin-1-yl}(4-chlorophenyl)methyl]benzonitrile, 47.2 mg (0.68 mmol) of hydroxylamine hydrochloride, 0.124 mL (0.9 mmol) of triethylamine, and 5 mL of ethanol was heated to reflux for 4 h. The solution was concentrated and the residue was poured into 20 mL of CH2Cl2 and 5 mL of aq NaHCO3 (PH>7). The aqueous layer was extracted with two 10 mL portions of CH2Cl2. The combined organic layer was dried over Na2SO4 and concentrated to afford the title compound as a white solid; Mass Spectrum: m/e=562 (M+1, 35Cl), 564 (M+1, 37Cl).

Provenance & Evidence