反应详情

[6-(2-methoxyethoxy)pyridine-3-yl]methanol (1.83 g 10.0 mmol) was dissolved in toluene (50 ml) and heated to reflux under an air condenser. Finely powdered MnO2 (4.0 g) was added portion wise over 2 hours. After a further 2 and a half hours of heating the mixture was taken off the boil allowed to cool slightly then filtered through celite and washed with toluene. The filtrate was concentrated in-vacuo to yield a pale yellow oil which crystallized under high vacuum to yield the crude product (1.50 g).

1. temperatureheated
2. temperatureto reflux under an air condenser
3. temperatureAfter a further 2 and a half hours of heating the mixture
4. temperatureto cool slightly
5. filtrationthen filtered through celite
6. washwashed with toluene
7. concentrationThe filtrate was concentrated in-vacuo
8. customto yield a pale yellow oil which
9. customcrystallized under high vacuum