化工社化工社 化学情報印刷レポート · 研究参考用
2-(tert-Butylamino)ethanol → 1-(Benzyloxy)-3-(tert-butyl(2-hydroxyethyl)amino)propan-2-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(tert-Butylamino)ethanol | HCID 78361 | — |
| 反応物 | Benzyl glycidyl ether | HCID 94247 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-(Benzyloxy)-3-(tert-butyl(2-hydroxyethyl)amino)propan-2-ol | HCID 57656862 | 83.5% |
反応手順
A solution of 2-[(benzyloxy)methyl]oxirane (350 mg) and 2-(tert-butylamino)ethanol (500 mg) in ethanol (20 mL) was heated to reflux temperature and left at this temperature overnight. The solution was concentrated at reduced pressure. The residue was purified by filtration through a short pad of silica eluting with 20% methanol in dichloromethane. This gave the title compound as a colourless oil (501 mg)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07906645B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-006fedb16250481cbc8dc74c7ccb5e7b |
| 出典メモ | uspto-grants-2011_03 |