Imidazole → HCID 54124222, compound

HRID 603282Notes

Reaction equation

HRID 603282 reaction equation
C([O:4][C:5]1[CH:14]=[C:13]2[C:8]([CH:9]=[C:10]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[CH:16]=3)[CH2:11][O:12]2)=[CH:7][CH:6]=1)(=O)C.N1C=CN=C1.O1C2C(=CC=C(O)C=2)C=C(C2C=CC(O)=CC=2)C1>C(O)C>[CH3:22][O:21][C:17]1[CH:16]=[C:15]([CH:20]=[CH:19][CH:18]=1)[C:10]1[CH2:11][O:12][C:13]2[C:8]([CH:9]=1)=[CH:7][CH:6]=[C:5]([OH:4])[CH:14]=2

Participants

5

Reactant 3

HCID 795ImidazoleHCID 219100PhenoxodiolHCID 54536887HCID 54536887, compound

Product 1

HCID 54124222HCID 54124222, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3′-MethoxyIsoflav-3-ene-7-ol was prepared from 7-acetoxy-3′-methoxyisoflav-3-ene (0.1 g, 0.3 mmol) and imidazole (0.15 g) in ethanol (2.0 ml) as described for isoflav-3-ene-4′,7-diol. Yield: (0.06 g, 70%) m.p. 75° C. 1H NMR (CDCl3): δ 3.84 (s, 3H, OMe), 5.12 (s, 2H, H2), 6.38 (d, 1H, J 2.0 Hz, H8), 6.40 (dd, 1H, J 2.0 Hz, 8.3 Hz, H6), 6.76 (bs, 1H, H4), 6.84 (dd, 1H, J 1.9 Hz, 8.3 Hz, ArH), 6.95 (m, 3H, ArH), 7.29 (t, 1H, J 8.3 Hz, ArH).

Sources & evidence

ORD record
ord-9f615fea3b7547bcbe901cca5dcb0a50
Source dataset
uspto-grants-2011_03
Patent number
US07906660B2

Reaction notes

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