Hydrochloric Acid → HCID 11186494, compound

Participants

Reaction Steps

A solution of Ethyl 4-(4-[(2,6-dimethylbenzyl)-thio]-phenyl)-4-oxobutyrate (Step D, 0.680 g, 2 mmol) in abs ethanol (20 ml) was treated with 1N NaOH (3 ml) at room temperature. The reaction mixture was stirred for 3 hours, acidified with 1M HCl and concentrated. The residue was taken in chloroform and washed with 0.1 M HCl, brine, dried over Na2SO4, filtered and concentrated. The purification was done by flash chromatography on a silica gel column (chloroform:methanol (95:5) spiked with acetic acid) to provide the title compound as off white solid.

Provenance & Evidence