HCID 67290358, compound → HCID 24739418, compound

Participants

Reaction Steps

A solution of ethyl 3-(benzylamino)-5-fluoro-4,4-dimethoxypentanoate (7, R1=ethyl, R2=methyl, R4=benzyl, R5=hydrogen, 32.1 g, 103 mmol) in methanol (321 mL) was treated with 10% palladium catalyst (10% Pd/C) under hydrogen atmosphere (1 atm) for 4 h. The crude mixture was filtered through a pad of Celite® (96 g), washed with methanol (160 mL), and the filtrate was concentrated under reduced pressure to give the title compound (1, R1=ethyl, R2=methyl, 21.4 g, 94%), which was used in the next reaction.

Provenance & Evidence