Chloroacetyl chloride → 2-Chloro-N-(2-chloro-4-fluoro-6-methylphenyl)-N-(4-methylphenyl)acetamide

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Reaction Steps

1.32 g of N-(2′-Chloro-4′-fluoro-6′-methylphenyl)-4-methylaniline is reacted with chloracetylchloride (1.76 g) at 90° C. for 30 minutes. The cooled mixture is stirred with toluene (20 ml) and aqu. sodium carbonate for 30 minutes and the organic phase is evaporated. The residue is purified flash-chromatography on silica using toluene affording 1.04 g of N-(2′-chloro-4′-fluoro-6′-methylphenyl)-N-chloroacetyl-4-methylaniline as a solid which is recrystallised from heptane/2-propanol (9:1), mp.: 96-97° C.

Provenance & Evidence