Aluminum(III) Chloride → HCID 11738308, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6.85 g (20 mmol) of N-(2′,6′-dichloro-4′-methylphenyl)-N-chloroacetyl-4-methylaniline and 3.36 g (26 mmol) of aluminium chloride was heated slowly to 160-170° C. and held at this temperature for 3-4 h. During this time, nitrogen was continuously bubbled into the melt. The mixture was diluted with 20 ml of toluene and added on 20 ml of warm water. The organic layer was separated, washed with water and evaporated. The residue was crystallised from 20 ml of 2-propanol giving N-(2′,6′-dichloro-4′-methylphenyl)-5-methyloxindole. Mp: 153-154° C.

Provenance & Evidence