HRID603428

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID702

Ethanol

C2H6O

HCID4158575

3-Chloro-2,4(3H,5H)-furandione

C4H3ClO3

结构：CCCc1cc(C(N)=S)ccc1OCCCOc1ccc2c(c1)CC[C@H]2CC(=O)OCC

HCID16110446

未命名化合物

PRODUCTS

生成物

结构：CCCc1cc(-c2nc(CO)c(C(=O)OCC)s2)ccc1OCCCOc1ccc2c(c1)CC[C@H]2CC(=O)OCC

HCID59300526

未命名化合物

收率 33%

CONDITIONS

反应条件

温度: 70 °C

PROCEDURE

实验过程

Ethyl ((1S)-5-{3-[4-(aminocarbonothioyl)-2-propylphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl)acetate (90 mg, 0.2 mmol) (Example 144) and 3-chloro-2,4(3H, 5H)-furandione (106 mg, 0.8 mmol) were dissolved in EtOH (anhydrous, 8 mL), and the mixture was heated at 70° C. for 18 h. The reaction was cooled to rt, and then concentrated under reduced pressure. Purification by silica gel flash chromatography (EtOAc:hexane (v/v)=1:1) gave 38 mg (33%) of the title compound as a clear oil. LC-MS: RT=4.38 min; (M+H)+ 582.3.

WORKUP

后处理

temperatureThe reaction was cooled to rt
concentrationconcentrated under reduced pressure
customPurification by silica gel flash chromatography (EtOAc:hexane (v/v)=1:1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-be2727a929f14fb1b11fa476c1aa549b
来源数据集: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07906653B2
来源说明: uspto-grants-2011_03

反应 SMILES

[NH2:1][C:2]([C:4]1[CH:29]=[CH:28][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[C@H:18]([CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:17][CH2:16]3)=[C:6]([CH2:30][CH2:31][CH3:32])[CH:5]=1)=[S:3].Cl[CH:34]1[C:38](=O)[CH2:37][O:36][C:35]1=[O:40].[CH3:41][CH2:42][OH:43]>>[CH2:26]([O:25][C:23](=[O:24])[CH2:22][C@H:18]1[C:19]2[C:15](=[CH:14][C:13]([O:12][CH2:11][CH2:10][CH2:9][O:8][C:7]3[CH:28]=[CH:29][C:4]([C:2]4[S:3][C:34]([C:35]([O:36][CH2:37][CH3:38])=[O:40])=[C:41]([CH2:42][OH:43])[N:1]=4)=[CH:5][C:6]=3[CH2:30][CH2:31][CH3:32])=[CH:21][CH:20]=2)[CH2:16][CH2:17]1)[CH3:27]